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March 12, 2026Open Forum Infectious DiseasesOpen Access

HIV Preexposure Prophylaxis Utilization and Reasons for Never Using Preexposure Prophylaxis Among Transfeminine Persons in the United States: Findings From the Transgender Women’s Internet Survey and Testing (TWIST) Study

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Authors

DIDuygu IslekTSTravis SanchezSBStefan Baral

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Overview

Cross-sectional survey examines PrEP use and barriers among transfeminine persons, indicating a need for tailored interventions.

Key Points

  • The research aims to evaluate PrEP utilization and identify reasons for non-use among transfeminine persons in the U.S.
  • National cross-sectional survey of transfeminine persons aged ≥15 years conducted online.
  • Participants recruited through the Transgender Women's Internet Survey and Testing (TWIST) Study.
  • Multivariable Poisson regression analysis used to estimate associations with current PrEP use.
  • Reasons for never using PrEP assessed descriptively by age group.
  • Only 6% of participants were currently using PrEP, while 86% had never used it.
  • Among current users, 94% used oral PrEP, with a small percentage using long-acting injectable PrEP.
  • Barriers identified included insurance-related concerns, side-effect worries, and relationship dynamics.
  • Younger participants cited privacy and transportation issues as primary reasons for not using PrEP.

Cite This Study

Islek et al. (2026) studied this question.

synapsesocial.com/papers/69b25b0996eeacc4fcec9503https://doi.org/10.1093/ofid/ofag073
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