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Experimental research demonstrates that targeting adipose tissue improves limb function in peripheral artery disease, suggesting new treatment approaches.
IMAT accumulation is a key determinant of limb function in PAD/CLTI. Our studies demonstrate that targeting IMAT formation could improve limb function in mice with experimental PAD. Together, these findings suggest that developing strategies to limit or reduce IMAT may improve limb function and walking performance in patients with PAD/CLTI, providing a novel therapeutic avenue to address a critical unmet need.
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Palzkill et al. (2026) studied this question.
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