Why the study?
Is intermuscular adipose tissue (IMAT) associated with insulin sensitivity and other adipose tissue compartments?
Is intermuscular adipose tissue (IMAT) associated with insulin sensitivity and other adipose tissue compartments?
IMAT can be quantified using standard MR techniques and is negatively correlated with insulin sensitivity, suggesting a role in the pathogenesis of insulin resistance.
IMAT may mark insulin resistance; hypothesis-generating and requires prospective trials before clinical adoption.
Quantification of IMAT is possible by standard MR techniques. AT distribution of the lower leg is comparable to the visceral compartment with males having higher IMAT/VAT but lower subcutaneous AT (SCAT). IMAT seems to be involved in the pathogenesis of insulin resistance, as shown by the significant negative correlation with GIR.
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Boettcher et al. (2009) studied this question.
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