Why the study?
Imaging techniques are increasingly used to quantify intermuscular adipose tissue (IMAT) non-invasively, but a comprehensive review of its definition, imaging, and clinical implications in T2DM was needed.
Non-invasive imaging of intermuscular adipose tissue provides important insights into its role in the pathogenesis and potential treatment of Type 2 diabetes mellitus.
Intermuscular adipose tissue (IMAT) is an ectopic fat depot found beneath the fascia and within the muscles. IMAT modulates muscle insulin sensitivity and triggers local and systemic chronic low-grade inflammation by producing cytokines and chemokines, which underlie the pathogenesis of Type 2 diabetes mellitus (T2DM). Imaging techniques have been increasingly used to non-invasively quantify IMAT in patients with diabetes in research and healthcare settings. In this study, we systematically reviewed the cell of origin and definition of IMAT, and the use of quantitative and functional imaging technology pertinent to the etiology, risk factors, lifestyle modification, and therapeutic treatment of diabetes. The purpose of this article is to provide important insight into the current understanding of IMAT and future prospects of targeting IMAT for T2DM control.
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Yu et al. (2022) studied this question.
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