Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health

Given the increasing availability of datasets such as the UK Biobank that (incidentally) include tens of thousands of genome-wide genotyped spousal pairs and large population biobanks with linked health record data for first-degree relatives, the offspring genotype-by-proxy MR approach could augment causal analyses of offspring perinatal exposures on their mother's outcomes as implementation is not restricted to datasets with mother-offspring genotype information.