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Mendelian randomization analysis reveals sleeplessness increases PCOS risk, indicating the need for sleep management.
Our MR analyses support a potential causal role of sleeplessness/insomnia in increasing the risk of PCOS, whereas the association with sleep apnea syndrome may be mediated by adiposity or other confounding factors. These findings highlight the importance of sleep management in strategies for the prevention of PCOS.
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Chen et al. (2026) studied this question.
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