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The review aims to compare umbilical cord blood and bone marrow as sources of hematopoietic stem cells for transplantation.

March 12, 2026Open Access

Umbilical Cord Blood versus Bone Marrow: A Comparative Review of Stem Cell Yield, Biological Properties, and Clinical Utility in Transplantation

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The review aims to compare umbilical cord blood and bone marrow as sources of hematopoietic stem cells for transplantation.
Narrative review of existing literature
Comparative analysis of biological properties
Assessment of clinical utility and outcomes
Umbilical cord blood shows advantages like immunological naivety and lower risk of graft-versus-host disease.
Bone marrow has higher hemopoietic stem cell yield per unit compared to cord blood.
Differences in cytokine profiles affect transplantation outcomes.

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This review evaluates hemopoietic stem cell sources, comparing umbilical cord blood and bone marrow, suggesting significant clinical implications.

Tijani et al. (2025) studied this question.

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This review evaluates hemopoietic stem cell sources, comparing umbilical cord blood and bone marrow, suggesting significant clinical implications.