Dual-Purpose Body and Face Formulation with Synergistic Actives for Thin, Aging, and Dry Skin: A Four-Week Clinical Study

Thin, dry skin is characterized by impaired barrier integrity, loss of dermal density, and accelerated aging driven by intrinsic and extrinsic factors. Biomimetic collagen peptides mimic native collagen sequences, stimulating fibroblasts to enhance synthesis while limiting matrix metalloproteinase-mediated degradation. This study evaluated the clinical efficacy and safety of a multi-ingredient cosmetic product for thin, dry, aging skin, formulated as a dual-purpose body and face serum lotion containing 0.1% biomimetic collagen tripeptide (Tripeptide-29) along with Niacinamide, Citrullus lanatus fruit extract, and Selaginella lepidophylla extract. In this prospective, single-center study, 47 healthy women, aged 36–65 years with Fitzpatrick skin types I–IV, applied the formula twice daily to the face and body over four weeks. Objective measurements—including elasticity, wrinkle depth and volume, hydration, trans-epidermal water loss (TEWL), and texture—were collected weekly alongside clinical grading and self-assessments. Significant improvements were observed across all parameters, with facial dryness decreasing immediately (−74.6%) and continuing to week 4 (−93.7%), hydration increasing up to 72.5%, softness improving up to 37.7%, roughness decreasing up to 37.9%, and TEWL reductions indicating strengthened barrier function. Desquamation improved by 75.5% by week 3, and no adverse effects occurred. The serum lotion demonstrated robust, well-tolerated benefits for enhancing multiple markers of thin, dry, aging skin.