Water-Compatible Acylation Reactions with Acid Chlorides Using a Flow Microreactor | Synapse
March 12, 2026Open Access
Water-Compatible Acylation Reactions with Acid Chlorides Using a Flow Microreactor
Key Points
To explore the effectiveness of acylation reactions using acid chlorides in a flow microreactor under aqueous conditions.
Utilized a flow microreactor for acylation reactions.
Performed reactions in a homogeneous aqueous medium.
Conducted quenched-flow analysis to monitor reaction progress.
Achieved up to 87% yield in acylation reactions.
Successfully suppressed hydrolysis in the aqueous medium.
Abstract
In this study, we used a flow microreactor for acylation with acid chlorides in a homogeneous aqueous medium, suppressing hydrolysis and providing up to 87% yield. Quenched-flow analysis indicated an...