Key result
Histopathological analysis confirmed aneurysmal fibrous histiocytoma in a patient, emphasizing its distinct features and the need for complete excision to reduce recurrence risk.
Histopathological analysis is crucial for accurately diagnosing aneurysmal fibrous histiocytoma and differentiating it from vascular neoplasms.
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Histopathology should guide complete excision; extends differentiation of aneurysmal fibrous histiocytoma from vascular neoplasms.
A 48-year-old male was referred to our skin cancer clinic with a 15-year history of a gradually enlarging, bleeding, tender 2 cm bluish nodule on his left upper chest. He had no significant medical history or systemic symptoms. Clinical examination revealed a solitary, tender nodule, and imaging suggested a vascular lesion. Histopathology confirmed aneurysmal fibrous histiocytoma (AFH), characterized by blood-filled spaces lacking endothelial lining, hemosiderin deposition, and inflammatory infiltrates. Immunohistochemically, the lesion expressed CD68 and factor XIIIa, differentiating it from vascular neoplasms. Complete excision reduces recurrence risk, but the patient deferred treatment. This case underscores the importance of histopathological analysis accurate diagnosis and management.
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Gafoor et al. (2026) studied this question. Histopathological analysis confirmed aneurysmal fibrous histiocytoma in a patient, emphasizing its distinct features and the need for complete excision to reduce recurrence risk.
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