April 1, 1995Histopathology
Aneurysmal benign fibrous histiocytoma: clinicopathological analysis of 40 cases of a tumour frequently misdiagnosed as a vascular neoplasm
Population
40 cases of the aneurysmal variant of cutaneous fibrous histiocytoma, presenting most commonly in middle-age…
Design
Case_series
Follow-up
mean 2.5 years (for 26 cases with follow-up)
Authors
Discussion
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Implication
Alerts clinicians to 19% local recurrence and vascular mimicry in this variant; leaves open larger series to guide management.
Key Points
- To characterize the clinicopathological and immunohistochemical spectrum of the aneurysmal variant of cutaneous fibrous histiocytoma to reduce frequent misdiagnosis as a vascular neoplasm.
- Retrospective clinicopathological analysis of 40 cases of aneurysmal cutaneous fibrous histiocytoma.
- Follow-up evaluation conducted in 26 cases with a mean duration of 2.5 years.
- Immunohistochemical profiling using the ABC method for vimentin, smooth muscle actin, CD68, CD31, CD34, desmin, and factor XIIIa.
- Tumors occurred predominantly in the lower limbs (50%), upper limbs (20%), and trunk (17%), with 19% local recurrence (5 of 26 cases with follow-up) and one case exhibiting lymph node involvement via direct extension.
- Histology revealed pseudovascular blood-filled spaces lacking endothelial linings, prominent hemosiderin deposition, siderophages, giant cells, peripheral hyalinized collagen, and epidermal hyperplasia in 88% of cases.
- Immunohistochemistry demonstrated uniform positivity for vimentin, occasional focal smooth muscle actin reactivity, and consistent negativity for CD31, CD34, desmin, and factor XIIIa.
Structured PICO
P
Population
40 cases of the aneurysmal variant of cutaneous fibrous histiocytoma, presenting most commonly in middle-age adults with a slight predilection for females.
O
Outcome
Clinicopathological features and local recurrence rate
Aneurysmal benign fibrous histiocytoma is a distinctive variant of cutaneous fibrous histiocytoma that can mimic vascular neoplasms and has a notable local recurrence rate of 19%.
Cite This Study
Calonje et al. (1995) studied this question.