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March 12, 2026

Proteoglycan Mimetics-Based Antimicrobial and Anti-Inflammatory Microneedles Restoring Dysregulated Lipid Metabolism and Suppressing Skin Atrophy for Acne Treatment.

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Authors

KDKehan DuMedical ProtectiveZYZhuo-Ran YangMedical ProtectiveLQLiya QiBeijing Chemical Industry Research Institute (China)

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Overview

Microneedles enhance acne treatment by restoring lipid metabolism and reducing skin atrophy, suggesting new therapeutic potential.

Key Points

  • This research aims to evaluate the effectiveness of proteoglycan-mimetic microneedles in treating acne and related skin issues.
  • Developed proteoglycan-mimetic dissolving microneedles containing therapeutic peptides.
  • Targeted acne-related pathways, including bacterial infection and inflammation.
  • Performed transcriptomic and metabolomic analysis to assess lipid metabolism and inflammation.
  • Evaluated effects on collagen synthesis and fibroblast functionality.
  • Significant reduction of Cutibacterium acnes infection.
  • Suppressed expression of pro-inflammatory mediators and altered macrophage ratios.
  • Regulated cholesterol and linoleic acid metabolism effectively.
  • Inhibited key signaling pathways related to inflammation and cellular growth.
  • Promoted collagen synthesis and improved fibroblast function, preventing skin atrophy.

Cite This Study

Du et al. (2026) studied this question.

synapsesocial.com/papers/69b25be596eeacc4fceca4b6https://doi.org/10.1002/smll.202512378
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Also Consider

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  1. 1Dissolved bubble microneedle patches for co-delivery of hydrophobic and hydrophilic drugs to improve acne vulgaris therapy2025 · 6 citations
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  3. 3Sponge‐Like Microneedles Spatially Sequester Chemokines and Deplete Monocytes to Alleviate Inflammatory Skin Disorders2024 · 6 citations
  4. 4Dissolved Bubble Microneedle Patches for Co-Delivery of Hydrophobic and Hydrophilic Drugs to Improve Acne Vulgaris Therapy2025
  5. 5Dissolving Hyaluronic Acid-Based Microneedles to Transdermally Deliver Eugenol Combined with Photothermal Therapy for Acne Vulgaris Treatment2024 · 23 citations