Key result
Multi-omics mapping yields aortic valve atlas and uncovers key regulatory networks driving CAVD.
Why the study?
Calcific aortic valve disease (CAVD) lacks a pharmacological cure and its molecular regulatory networks have not been identified.
Population
Calcific aortic valve disease (CAVD)
Comparison
Spatiotemporal multi-omics mapping and network/systems biology strategy
Design
Spatially and temporally resolved multi-omics and network systems biology study
Authors
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No immediate clinical implications for CAVD; leaves open a novel ontology framework for cardiovascular research.
A multi-omics strategy successfully mapped the molecular regulatory networks driving calcific aortic valve disease, providing a novel framework for cardiovascular disease ontology.
Schlotter et al. (2018) studied this question. Spatiotemporal multi-omics mapping generated a molecular atlas of the aortic valve and identified the first molecular regulatory networks driving calcific aortic valve disease.
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