A multi-omics strategy successfully mapped the molecular regulatory networks driving calcific aortic valve disease, providing a novel framework for cardiovascular disease ontology.
A spatially and temporally resolved multi-omics, and network and systems biology strategy identifies the first molecular regulatory networks in CAVD, a cardiac condition without a pharmacological cure, and describes a novel means of systematic disease ontology that is broadly applicable to comprehensive omics studies of cardiovascular diseases.
Schlotter et al. (Tue,) studied this question.