Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 13, 2026International Journal of Innovative Technologies in Social ScienceOpen Access

Beyond Triptans: Systematic Review Focusing on the Efficacy and Safety Profile of CGRP Receptor Antagonists in Migraine Management

View Full Paper
Ask AI
Bookmark
Share

Authors

MSMikołaj SzulewskiGBG. BajorZGZofia Gniadek

Discussion

Loading...

Member takes

Overview

Systematic review reveals CGRP receptor antagonists effectively reduce migraine days in adults, indicating a promising alternative therapy.

Key Points

  • This study evaluates the clinical efficacy and safety of CGRP receptor antagonists, known as gepants, in migraine management.
  • Conducted a systematic review using PubMed and other literature sources.
  • Focused on clinical trials, RCTs, and meta-analyses related to gepants.
  • Analyzed data on efficacy in both preventive and acute migraine treatment.
  • Gepants significantly reduce mean monthly migraine days compared to placebo.
  • Efficacy demonstrated in acute migraine treatment with notable pain relief.
  • Safety profiles of gepants are comparable to placebo and do not cause vasoconstrictive effects.

Cite This Study

Szulewski et al. (2026) studied this question.

synapsesocial.com/papers/69b3aaa802a1e69014ccb6fchttps://doi.org/10.31435/ijitss.1(49).2026.5037
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The pharmacology of gepants in migraine: A scoping review on mechanisms, clinical applications, and combination strategies2026 · 2 citations
  2. 2Integrating gepants into clinical practice for the acute treatment of migraine2026
  3. 3Safety and Tolerability of Combining CGRP Monoclonal Antibodies with Gepants in Patients with Migraine: A Retrospective Study2024 · 35 citations
  4. 4Optimizing Migraine Therapy: A Comparative Review of Dosage and Tolerability of Calcitonin Gene Related Peptide Antagonists2025
  5. 5Rimegepant - a breakthrough drug for migraine treatment - literature review2024