Real-time nanopore technology determines DNA-drug interactions, suggesting advancements in drug discovery.
Front Cover In article number e01003, Guan and co-workers developed a real-time label-free nanopore method for simultaneous determination of binding mode, kinetics and thermodynamics of DNA-drug interactions, as well as for investigating drug-induced structural or diameter change in DNA from a single measurement. This nanopore platform shows promise as a tool for routine drug screening and discovery.
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Zheng et al. (2026) studied this question.
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