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March 13, 2026SHILAP Revista de lepidopterologíaOpen Access

Sexual Dimorphism in Renal Progenitors: Do Immunosuppressants Erase the Female Advantage?

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Authors

ZUZeynep Ural

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Overview

Explores immunosuppressants' impact on kidney function differences between sexes, suggesting implications for treatment customization.

Key Points

  • The study investigates how immunosuppressants affect the biological advantages seen in female renal progenitors and kidney function compared to males.
  • Reviewed sex-based differences in chronic kidney disease and kidney transplantation outcomes.
  • Analyzed estrogen's role in renal protection and progenitor activation through specific molecular pathways.
  • Evaluated the effects of calcineurin inhibitors and mTOR inhibitors on renal resilience and function in females and males.
  • Estrogen promotes renal health by enhancing progenitor proliferation and reducing inflammation in women.
  • Transplant-related immunosuppressants negate the protective effects of estrogen, leading to equal outcomes between sexes.
  • Future approaches could include sex-specific immunosuppressive strategies to preserve renal advantages in women.

Cite This Study

Zeynep Ural (2026) studied this question.

synapsesocial.com/papers/69b3ab0002a1e69014ccbbfchttps://doi.org/10.3389/ti.2026.16092
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gender and kidney transplantation2024 · 5 citations
  2. 2The role of estrogen in cardiac transplantation: mechanistic insights and effects on clinical outcomes2026
  3. 3Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation2026
  4. 4Gender disparities in kidney transplant access and outcomes: a population-based analysis2025
  5. 5Sex-dependent differences in the progression of renal injury and fibrosis following ischemic acute kidney injury2026 · 3 citations