Parameter-screened LED therapy targets STAT3/IL-6 axis to attenuate tendinopathy via dual modulation of inflammation and ECM remodeling

Key Points

• The research aims to investigate how LED therapy can restore tendon health by targeting the STAT3/IL-6 signaling pathway.
• Examined the effects of IL-1β on tendon homeostasis.
• Administered LED therapy at 625 nm with a dosage of 52.8 J/cm².
• Analyzed changes in STAT3 activity and IL-6 expression after treatment.
• LED therapy countered the inflammatory effects of IL-1β on tendon tissue.
• Restoration of STAT3 activity was observed post-LED treatment.
• IL-6 expression levels were significantly suppressed by LED therapy.