Enhanced ion utilization efficiency in IMS-TOFMS using a novel gate-free traveling wave ion guide

Key Points

• The research aims to enhance ion utilization efficiency in ion mobility spectrometry-mass spectrometry (IMS-MS).
• Developed a novel gate-free traveling wave ion guide for IMS-MS.
• Evaluated ion separation and detection capabilities with the new ion guide.
• Conducted assessments in a metabolomics context using electrospray ionization.
• Achieved significant improvements in ion detection rates.
• Demonstrated enhanced resolution in ion separation.
• Showed greater sensitivity compared to traditional ion guides.