This research demonstrates a correlation between gene copy number variations and antimalarial resistance in P. falciparum, indicating urgent implications for treatment strategies in Northeast India.
A statistically significant positive correlation was observed between mutations in the Pfdhfr and Pfdhps genes and increased CNVs in the Pfgch1 gene. Further investigation is needed to elucidate the correlation between Pfgch1 amplification and how Pfdhfr/Pfdhps mutations contribute to antimalarial drug resistance in P. falciparum. This research finding may help to detect and mitigate the spread of antifolate-resistant P. falciparum.
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Sen et al. (2026) studied this question.
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