Researchers synthesized pyridine-fused heterocyclic compounds to improve characteristics of pharmacologically active drugs, suggesting potential benefits in drug development.
Owing to their distinctive physicochemical features, their structural analogues of benzene ring bioisosteres, and their strong affinity for biomacromolecules, pyridine derivatives function both as core structural scaffolds in pharmacologically active compounds and as versatile elements for optimizing key drug-like properties, such as water solubility, membrane permeability, and metabolic stability. In this study, we synthesized five pyridine-fused heterocyclic compounds using common synthetic intermediates as precursors.
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Li et al. (2026) studied this question.
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