What question did this study set out to answer?

The aim is to assess the effectiveness of shorter antitubercular regimens compared to traditional 9-month Isoniazid therapy in children with latent tuberculosis infection (LTBI).

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March 13, 2026Open Access

Shorter Antitubercular Regimens Versus 9 Months of Isoniazid for Latent Tuberculosis in Children: A Systematic Review and Meta-Analysis

Key Points

The aim is to assess the effectiveness of shorter antitubercular regimens compared to traditional 9-month Isoniazid therapy in children with latent tuberculosis infection (LTBI).
Conducted a systematic review and meta-analysis of existing studies
Evaluated treatment completion rates and safety outcomes
Compared rifamycin-containing regimens to standard 9-month Isoniazid therapy
Shorter rifamycin-based regimens likely improve treatment completion rates in children
Safety outcomes are comparable between shorter regimens and standard treatment
No significant differences in the development of TB disease were found between the regimens

Abstract

Shorter rifamycin-containing regimens for pediatric TBI probably increase treatment completion and have similar safety outcomes, with no important difference in development of TB disease compared with the standard regimen. These findings support current guideline recommendations that favor shorter regimens in children.

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Cite This Study

Kosenko et al. (Fri,) studied this question.

synapsesocial.com/papers/69b3ab9102a1e69014ccc8d2 https://doi.org/https://doi.org/10.1093/cid/ciag073

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