A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization

Xin Bao; Jingyan Sun; Xing Gao; Min Xu; Chen Dong; Honghua Pan

doi:10.1039/d5ra08918b

January 1, 2026RSC AdvancesOpen Access

A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization

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Key Points

This research aims to evaluate a hydrogel system that enhances spinal cord injury repair by targeting multiple biological pathways.
Developed a photothermal-responsive hydrogel for therapy.
Integrated antioxidative and neuroprotective functions within the hydrogel.
Assessed hydrogel effects on macrophage polarization and calcium influx in spinal cord injury models.
The hydrogel improved spinal cord repair outcomes compared to traditional treatments.
Demonstrated significant reduction in reactive oxygen species (ROS).
Inhibited calcium influx and altered macrophage polarization, enhancing neuroprotection.

Implication

Novel hydrogel demonstrates enhanced repair outcomes in spinal cord injury, suggesting new therapeutic approaches.

Abstract

A novel photothermal-responsive hydrogel enables multi-target therapy for spinal cord injury by synergistically integrating anti-oxidative, anti-inflammatory, and neuroprotective functions

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Cite This Study

Bao et al. (2026) studied this question.

synapsesocial.com/papers/69b3aba202a1e69014cccae2 https://doi.org/10.1039/d5ra08918b

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A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization

Key Points

Implication

Abstract

Discussion

Cite This Study

A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization

Key Points

Implication

Abstract

Discussion

Cite This Study

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