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March 13, 2026Hemoglobin

Comparative Analysis of Erythroferrone and Hepcidin as Emerging Biomarkers of Iron Homeostasis in Patients with β-Thalassemia Major: A Case-Control Study from Pakistan

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Authors

SBSadia BabarBaqai Medical UniversityMSMuhammad Younus Jamal SiddiqiBaqai Medical UniversityMRMuhammad RizwanIslamia University of Bahawalpur

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Overview

Case-control study compares erythroferrone and hepcidin in beta-thalassemia major, suggesting need for targeted interventions.

Key Points

  • Evaluate erythroferrone and hepcidin levels in beta-thalassemia major patients versus healthy controls.
  • Cross-sectional design with 85 participants
  • Blood samples collected 2 weeks post-transfusion
  • Immunoassay used to measure ERFE and hepcidin levels
  • ERFE levels significantly higher in patients (90.00 ng/ml) than controls (19.30 ng/ml)
  • Hepcidin levels lower in patients (22.80 ng/ml) versus controls (49.55 ng/ml)
  • Ferritin significantly elevated in patients at 2998.00 ng/ml
  • Inverse correlation between ERFE and hepcidin (ρ = -0.408)
  • Positive correlation between ERFE and ferritin (ρ = 0.320)

Cite This Study

Babar et al. (2026) studied this question.

synapsesocial.com/papers/69b3abb202a1e69014cccd20https://doi.org/10.1080/03630269.2026.2637574
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum Erythroferrone Level and Its Relation to Iron Overload in Patients with Βeta-Thalassemia2026 · 1 citations
  2. 2Erythroferrone and hepcidin levels in children with iron deficiency anemia2024 · 10 citations
  3. 3Comparative Analysis of the Age, Gender, and Ferritin Levels with Hepcidin in Iraqi Patients Suffering Beta Thalassemia (Major and Intermedia)2025
  4. 4Association Between IL-10 and Serum Hepcidin in Patients with β-Thalassemia Major: A Case-Control Study Using Multiple Statistical Modeling2026
  5. 5Association Between Serum Ferritin Level and Liver Function Tests in Children with Beta-Thalassemia (Thalassemia Center of Kut Hospital, Iraq)2024