Reveals mechanisms of glioma progression in LGG to GBM, suggesting potential biomarkers for treatment.
In summary, glioma grade progression and histological transformation were complex biological processes, which involved the abnormal up-regulation of Ras/p38-MAPK signalings, enhanced non-MGMT dependent unspecific DNA damage repair system regulated by RFC complex and metabolic reprogramming based on HK1-PFKP-ENO2 mediated glycolysis and peroxisomal FA beta oxidation. This study filled the gap in relevant research on the grade progression and histological transformation of LGG, providing novel and unique insights into the biological mechanisms of glioma progression.
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Huang et al. (2026) studied this question.
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