Bicarbonate and Other Buffer Therapies in Acute Metabolic Acidosis: A Systematic Review and Meta‐Analysis
Key Points
To evaluate the effectiveness of buffer therapies, particularly bicarbonate, in treating acute metabolic acidosis in critical care settings.
Conducted a systematic review of existing literature on buffer therapies for metabolic acidosis.
Performed a meta-analysis to synthesize data on treatment outcomes.
Focused on studies primarily within critical care environments.
Bicarbonate therapy shows mixed results in improving outcomes for metabolic acidosis.
Buffer therapies may have a role in specific patient populations within critical care.
Evidence indicates a need for cautious application of bicarbonate treatment.
Abstract
This systematic review with meta-analysis presents an up to date and trustworthy synthesis of evidence concerning buffer therapy in acute metabolic acidosis, largely focused in the critical care context.