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A case reports multiple cerebral abscesses linked to Acanthamoeba infection in a child with gp91phox deficiency, indicating the need for respiratory burst evaluation.
Rare variants in CYBB (encoding gp91phox) are responsible for chronic granulomatous disease. We report a patient affected by multiple cerebral abscesses caused by Acanthamoeba sp. and complete gp91phox deficiency. The respiratory burst evaluation is recommended in any child with a deep abscess.
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Roelens et al. (2026) studied this question.
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