Consecutive reaction demonstrates radical coupling in 2-alkynylthioanisoles, suggesting efficient synthesis methods.
We describe a consecutive reaction of 2-alkynylthioanisoles and 4-cyanopyridine enabled by EDA complex photoactivation, which facilitates the sequential S-α-C(sp 3 )–H bond activation, cyclization and radical coupling under mild conditions.
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Xu et al. (2026) studied this question.
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