What question did this study set out to answer?

The aim is to explore a new method for S-α-C(sp3)–H functionalization using photoinduced reactions.

March 13, 2026Chemical Science0 citationsOpen Access

Photoinduced intramolecular S-α-C(sp 3 )–H functionalization enabled by an electron donor–acceptor complex-Mediated radical relay

TXTiantian XuAnhui Polytechnic University RHRan HongAnhui Polytechnic University TLTong LüAnhui Polytechnic University

Key Points

The aim is to explore a new method for S-α-C(sp3)–H functionalization using photoinduced reactions.
Utilized electron donor-acceptor (EDA) complex for photoactivation.
Performed reactions with 2-alkynylthioanisoles and 4-cyanopyridine.
Conducted reactions under mild conditions for effective activation and coupling.
Achieved successful S-α-C(sp3)–H bond activation and cyclization.
Demonstrated efficient radical coupling in the reaction process.

Abstract

We describe a consecutive reaction of 2-alkynylthioanisoles and 4-cyanopyridine enabled by EDA complex photoactivation, which facilitates the sequential S-α-C(sp 3 )–H bond activation, cyclization and radical coupling under mild conditions.

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