What question did this study set out to answer?

To evaluate the safety and feasibility of using uncrossmatched whole blood transfusion in civilian non-trauma patients.

March 13, 20260 citations

Safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian non-trauma patients.

EFEmmanuel A. FadeyiAtrium Health Wake Forest Baptist JCJoshua Cox-Jones JSJordan StaggsAtrium Health Wake Forest Baptist

Key Points

To evaluate the safety and feasibility of using uncrossmatched whole blood transfusion in civilian non-trauma patients.
Comparative analysis of whole blood transfusion outcomes in non-trauma patients
Assessment of 24-hour in-hospital mortality
Monitoring for transfusion-related adverse effects
Whole blood transfusion is linked to lower 24-hour in-hospital mortality rates
No increase in adverse effects related to transfusion
Effective for emergently treating severely hemorrhaging non-trauma patients

Abstract

This study demonstrates that the use of WB in non-trauma patients is associated with a decreased 24 h in-hospital mortality with either operative or GI bleed when compared to nonoperative WB transfusion. Emergent severely hemorrhaging non-trauma patients can receive WB transfusions safely without any increased transfusion related adverse effects.

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