Systematic review reports a modest increase in breast cancer risk with hormonal therapy, indicating geographical variations.
MHT is associated with a modest but significant increase in breast cancer risk, primarily driven by EPT. This risk was not observed with ET in observational studies, though trials suggested a protective effect. Crucially, the association shows marked geographical heterogeneity, indicating risk is modified by regimen and regional factors.
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Wu et al. (2026) studied this question.
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