Pilot RCT explores safety of sNO in ECMO, suggesting further investigation of its effects is needed.
This single-center pilot RCT of sNO vs. standard sweep flow in the ECMO circuit demonstrated that such a trial is safe and feasible. However, given no effect of sNO on clinical outcomes was detected further exploration of dose and route of administration of NO should be undertaken before larger, definitive trials are conducted.
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Mattke et al. (2026) studied this question.
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