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March 13, 2026Archives of ToxicologyOpen Access

Neurodevelopmental effects of methylmercury (MeHg): a review of epidemiological points of departure (PoDs), toxicological reference values (TRVs), and key uncertainties in human health risk assessment

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Authors

SBScott R. BlechingerHealth CanadaKSKavita SinghHealth CanadaAAAbdul AfghanHealth Canada

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Implication

This review examines neurodevelopmental impacts of methylmercury in children, highlighting uncertainties in risk assessment methods.

Key Points

  • The aim is to review the neurodevelopmental effects of methylmercury and assess the reliability of toxicological reference values in human risk assessments.
  • Reviewed historical epidemiological studies from New Zealand, Faroe Islands, and Seychelles.
  • Analyzed methodologies used by regulatory agencies to derive toxicological reference values.
  • Identified uncertainties and gaps in observational epidemiology data.
  • Most agencies have good agreement on toxicological reference values despite differing methodologies.
  • Highlighted uncertainties in the use of data for deriving values, particularly in observational studies.
  • Emerging studies suggest the need for reassessment of existing reference values.

Cite This Study

Blechinger et al. (2026) studied this question.

synapsesocial.com/papers/69b3ac8102a1e69014cce3eahttps://doi.org/10.1007/s00204-026-04345-8
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury1997 · 1,744 citations
  2. 2METHYL MERCURY EXPOSURE IN NORTHERN QUEBEC: II. NEUROLOGIC FINDINGS IN CHILDREN1983 · 287 citations
  3. 3Calculation of Benchmark Doses from Continuous Data1995 · 412 citations
  4. 4Relationship of prenatal methylmercury exposure and language/verbal function: a meta-analysis2025 · 4 citations