Key result
Primary pulmonary DLBCL presents with significant LA invasion and a 95% Ki-67 proliferative index.
Why the study?
Primary pulmonary lymphoma is uncommon, and cardiac extension via the pulmonary vein is exceptionally rare.
Highlights a rare case of primary pulmonary diffuse large B-cell lymphoma with cardiac extension into the left atrium, emphasizing the need for comprehensive imaging and immunophenotyping.
Answers are grounded in this paper and cite their sources.
May warrant multimodality imaging for cardiac involvement in pulmonary DLBCL; extends reports of rare intracardiac extension by aggressive lymphomas.
Primary pulmonary lymphoma is an uncommon entity, accounting for <1% of all non-Hodgkin lymphomas and <0.5% of primary lung tumors. Cardiac extension via the pulmonary vein is exceptionally rare. We report a case of a 55-year-old postmenopausal female with hypothyroidism and rheumatoid arthritis who presented with progressive dyspnea and significant weight loss. Imaging revealed a large fluorodeoxyglucose-avid mass in the right lower lobe of the lung extending into the left atrium with tumor thrombus, mediastinal lymphadenopathy, and adrenal involvement. Histopathology and immunohistochemistry confirmed diffuse large B-cell lymphoma (DLBCL) with a high proliferative index (Ki-67: 95%). This case emphasizes the importance of comprehensive imaging and immunophenotyping in diagnosing atypical thoracic masses.
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Mauryakrishna et al. (2026) studied this question. A 55-year-old female with primary pulmonary diffuse large B-cell lymphoma presented with significant left atrial invasion and a high Ki-67 proliferative index.
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