What does this research mean for the field?

Benzimidazole derivatives exhibit a wide range of biological activities, including antibacterial, anticancer, antiviral, anti-inflammatory, analgesic, antifungal, antioxidant, antidiabetic, antihypertensive, anticoagulant, and antidepressant effects, making them promising leads for new drug design. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review examines the chemistry of benzimidazoles, focusing on their synthesis and various therapeutic potentials.

March 13, 2026JOURNAL of QASSIM UNIVERSITY FOR SCIENCE

Recent Advances in Benzimidazole Chemistry: A Comprehensive Review on Synthetic Approach and Therapeutic Potential

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Authors

OAOmar Ghazi AlmohammdiQassim University FAFahad Mohammad AlminderejQassim University LALotfi M. ArouaQassim University

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Implication

Comprehensive review details synthetic methods and biological activities of benzimidazole derivatives, highlighting drug development implications.

Key Points

This review examines the chemistry of benzimidazoles, focusing on their synthesis and various therapeutic potentials.
Overview of benzimidazole properties and biological importance
Classification of synthetic approaches including various reactions
Evaluation of green chemistry methods for benzimidazole synthesis
Summary of biological activities relevant to drug discovery
Benzimidazole derivatives show antibacterial effects against Gram+ and Gram- bacteria
Exhibit strong anticancer activity against diverse cell lines and enzymes
Demonstrate antiviral properties against HIV and TMV
Present anti-inflammatory, analgesic, antifungal, antioxidant, antidiabetic, antihypertensive, anticoagulant, and antidepressant effects

Cite This Study

Almohammdi et al. (2026) studied this question.

synapsesocial.com/papers/69b3acd302a1e69014ccee9f https://doi.org/10.25259/jqus_5_2025

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Implication

Comprehensive review details synthetic methods and biological activities of benzimidazole derivatives, highlighting drug development implications.

Recent Advances in Benzimidazole Chemistry: A Comprehensive Review on Synthetic Approach and Therapeutic Potential

Discussion

Member takes

Implication

Key Points

Cite This Study

Recent Advances in Benzimidazole Chemistry: A Comprehensive Review on Synthetic Approach and Therapeutic Potential

Discussion

Member takes

Implication

Key Points

Cite This Study

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