Case-control study shows APOL1-HR genotype protects against kidney disease, suggesting its role as a genetic modifier.
In this case-control study of 107 696 individuals, presence of an APOL1-HR genotype M1 was significantly associated with protection against kidney disease, suggesting that it may have a role as a genetic modifier. Patients with CKD with an APOL1-HR genotype and M1 should be evaluated for an alternative and potentially treatable cause of their CKD.
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Martinelli et al. (2026) studied this question.
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