What question did this study set out to answer?

To characterize phenolic reaction products from nitrogen mustards and N,N-dialkylaminoethyl-2-chlorides using ESI-MS/MS techniques.

March 13, 2026Rapid Communications in Mass Spectrometry0 citations

View Full Paper

ESI–MS/MS Characterisation of Phenolic Reaction Products of Nitrogen Mustards and N , N ‐Dialkylaminoethyl‐2‐Chlorides and Their Rapid Screening by LC–MS/MS in Neutral Loss Scan Mode

MSM. Nikita SinghIndian Institute of Chemical Technology KHK. G. HarshaIndian Institute of Chemical Technology VLV. V. S. LakshmiIndian Institute of Chemical Technology

Key Points

To characterize phenolic reaction products from nitrogen mustards and N,N-dialkylaminoethyl-2-chlorides using ESI-MS/MS techniques.
Utilized ESI-MS/MS for product ion spectra analysis of compounds.
Developed an LC-MS/MS neutral-loss scan method for screening.
Focused on isomer differentiation in reaction products.
Validated screening method demonstrated efficiency in complex samples.
Identification of unique phenolic markers was achieved.
Methods are applicable for OPCW proficiency testing and CWC verification.

Abstract

Phenolic reaction products of nitrogen mustards and N,N-dialkylaminoethyl-2-chlorides were comprehensively characterised, including isomer differentiation, through their ESI-MS/MS product ion spectra. The validated LC-MS/MS neutral-loss scan method enabled efficient screening of these markers in complex samples. These LC-MS/MS methods are highly valuable for OPCW proficiency testing and CWC verification programs.

Ask AI

Helpful

Bookmark

View Full Paper

Ask AI

Helpful

Bookmark

View Full Paper

ESI–MS/MS Characterisation of Phenolic Reaction Products of Nitrogen Mustards and N , N ‐Dialkylaminoethyl‐2‐Chlorides and Their Rapid Screening by LC–MS/MS in Neutral Loss Scan Mode

Key Points

Abstract

Cite This Study