Synthesis reveals dynamic chirality and stereochemical stability in planar chiral diallylic amides, indicating potential applications in drug development.
A variety of C3- or C4-substituted diallylic 9-membered amides have been synthesized via the coupling reaction of iodinated intermediates, which were efficiently synthesized from 7-membered hemiaminals. The presence of the dynamic chirality of the newly synthesized amides and their stereochemical stability were revealed.
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Uehara et al. (2026) studied this question.
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