Enantioselective addition developed to form 2-alkylpyridines with multiple stereocenters, implying enhanced control over product configurations.
A direct enantioselective conjugate addition of 2-alkylpyridines enables efficient construction of complex functionalized pyridinyl scaffolds with contiguous stereocenters. This method leverages chiral lithium amides as traceless stereodirecting auxiliaries, operating through defined aggregation of organolithium intermediates to achieve excellent enantio- and diastereocontrol.
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Ly et al. (2025) studied this question.
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