This method demonstrates enhanced alkylation of fused bicyclic pyridines, indicating broad applicability in pharmaceuticals.
Pyridines and nitrogen containing heterocycles comprise a large portion of pharmaceutical compounds and have many practical applications. Herein, we describe a straightforward, enantioselective method for direct alkylation of fused bicyclic pyridines, using chiral lithium amides as traceless auxiliaries. This method is tolerant of a variety of activated electrophiles which can allow for further functionalization.
No takes yet. Share an insight, caveat, or question.
Chambers et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: