What question did this study set out to answer?

Metabolomics study on anti-inflammatory effects of Guanjie Zhentong Babu plaster on collagen-induced arthritis rats

View Full Paper

Ask AI

Bookmark

Authors

Metabolomics reveals anti-inflammatory effects of Guanjie Zhentong Babu against collagen-induced arthritis, suggesting pathways for treatment.

To investigate the anti-inflammatory effects of Guanjie Zhentong Babu Plaster on collagen-induced arthritis in rats.
Rats developed collagen-induced arthritis were treated with Guanjie Zhentong Babu Plaster.
Histopathological changes assessed post-treatment using hematoxylin–eosin staining.
Serum metabolite profiles analyzed using ultra-high-performance liquid chromatography.
The arthritis index was evaluated at multiple time points to assess treatment effects.
Inflammatory markers TNF-α, IL-17, and IL-10 were measured via immunohistochemistry and ELISA.
High-dose cold syndrome group exhibited significant improvement in arthritis index scores after 14 days (<P < 0.05).
Ankle joint swelling was significantly reduced in the high-dose group (<P < 0.01).
Marked restoration of arginine and purine metabolism pathways following treatment with Guanjie Zhentong Babu Plaster.
Decreased levels of TNF-α and IL-17, and increased IL-10 levels in treating groups compared to model group.

Xu et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Metabolomics reveals anti-inflammatory effects of Guanjie Zhentong Babu against collagen-induced arthritis, suggesting pathways for treatment.