What question did this study set out to answer?

To evaluate how purification procedures affect PBMC quality indicators and propose new metrics.

March 14, 2026PLoS ONEOpen Access

Comparing PBMC isolation approaches and assessing epigenetic immune cell quantification as quality control for PBMCs

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Experimental analysis evaluates purification procedures for PBMC quality, indicating anti-coagulants impact cell count and monocyte recovery.

To evaluate how purification procedures affect PBMC quality indicators and propose new metrics.
Compared different PBMC isolation approaches
Measured purity and cell count indicators
Introduced epigenetic analysis as a performance metric
Sample quality significantly varied with anti-coagulants and purification procedures
True recovery of monocytes was highlighted as a better quality metric
Granulocyte contamination was primarily influenced by time before PBMC purification

Heller et al. (2026) studied this question.

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Experimental analysis evaluates purification procedures for PBMC quality, indicating anti-coagulants impact cell count and monocyte recovery.