Electrochemical synthesis yields 1,2-substituted N-amido benzimidazoles from nitroarenes, highlighting their pharmacological potential.
Despite the vast number of reports on benzimidazoles, 1,2-substituted N-amido benzimidazoles remain an underrepresented and scarcely accessible compound class with promisingpharmacological relevance. We present a safe, reliable electrochemical protocol that provides easy access to those structures. The reaction exhibits broad functional group tolerance and affords the target compounds in ≤89% yields.
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Doellerer et al. (2026) studied this question.
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