Design of a multichannel transcranial stimulation system shows controlled electrical stimulation of deep brain regions, indicating effective individualized treatment strategies.
Key Points
To design and verify a system for precise deep brain stimulation using multichannel transcranial temporal interfering stimulation (tTIS) based on individual MRI.
Designed a multichannel tTIS system utilizing an individual's MRI image.
Applied a parallel genetic algorithm with GPU for optimization.
Verified performance using a modeled head circuit to simulate deep brain stimulation.
Controlled misstimulation rates to below 2% when stimulating the left thalamus with four or more electrodes.
Reduced average stimulus application by 77.9% without deep-brain modeling.
Achieved a 98.21% coefficient of determination for predicted signal modulations.