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March 12, 2026Current Opinion in Nephrology & Hypertension

Implications of the cystatin C/creatinine discordance

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Key Points

The aim is to understand the relationship between cystatin C and creatinine in estimating kidney function.
Examined eGFRdiff in relation to adverse health outcomes
Considered accuracy of eGFRcr versus eGFRcys
Emphasized the use of combined equation estimates
Cystatin C levels provide essential insights into kidney function accuracy
The relationship between eGFRdiff and adverse outcomes is complex
Guidelines suggest favoring combined equations for better evaluation

Implication

Analyzing discordance of cystatin C and creatinine impacts eGFR accuracy, suggesting combined estimates for better outcomes.

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Cite This Study

Ian E. McCoy (2026) studied this question.

synapsesocial.com/papers/69b4b9fb18185d8a39802498 https://doi.org/10.1097/mnh.0000000000001178

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Discordances Between Creatinine- and Cystatin C–Based Estimated GFR and Adverse Clinical Outcomes in Routine Clinical Practicecohort · 2023 · 110 citations
2Cystatin C- and Creatinine-based Estimated GFR Differences: Prevalence and Predictors in the UK Biobank2024 · 25 citations
3Improved estimation of glomerular filtration rate (GFR) by comparison of eGFR<sub>cystatin C</sub>and eGFR<sub>creatinine</sub>cohort · 2011 · 89 citations
4Cystatin C in chronic kidney disease: enhancing diagnostic accuracy and patient outcomes.Review · 2026 · 3 citations
5Discrepancies Between Creatinine- and Cystatin C-Based eGFR Estimation in Palliative Care Patients and Their Implications on Drug Dosing.other · 2026