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March 14, 2026Neuro-Oncology PediatricsOpen Access

CNSC-06. Brainstem neuromodulatory neurons promote glioma growth locally and via long-range projections to midline and cortical structures

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Authors

RDRichard DrexlerADAntonia DrinnenbergAGAvishai Gavish

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Overview

Optogenetic stimulation enhances glioma growth in pons and neocortex, indicating cholinergic neurons are critical mediators.

Key Points

  • This research investigates the role of brainstem neuromodulatory neurons in promoting glioma growth.
  • Utilized optogenetic stimulation of serotonergic and cholinergic neurons in mice with DMG allografts or xenografts.
  • Analyzed circuit-specific effects on glioma proliferation in various brain regions including the neocortex and pons.
  • Conducted co-culture experiments to observe synaptic interactions between neuromodulatory neurons and glioma cells.
  • Stimulation of cholinergic neurons increased glioma proliferation in the pons and neocortex.
  • Distinct receptor profiles correlated with glioma growth, particularly with M1 and M3 cholinergic receptors.
  • Identified synaptic structures indicating neuron-glioma interactions.

Cite This Study

Drexler et al. (2025) studied this question.

synapsesocial.com/papers/69b4ba0818185d8a3980278bhttps://doi.org/10.1093/neuped/wuaf001.025
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