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March 11, 2026British Journal of PharmacologyOpen Access

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

Laia Blanco‐Casoliva Lidia Puertas‐Umbert Judith Alonso Rafael Almendra‐Pegueros Saray Varona Mercedes Camacho Gemma Arderiu L Asmarats M. Alegret Jose Martinez‐Gonzalez C R Rodriguez

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Key Points

This research investigates the role of thrombospondin-4 in abdominal aortic aneurysm (AAA) and its effects on vascular health.
Analyzed thrombospondin-4 expression in abdominal aortic aneurysm cases.
Examined the pathway modulation of thrombospondin-4.
Evaluated the impact on vascular inflammation and remodelling.
Thrombospondin-4 is significantly upregulated in AAA.
It shows a protective effect against vascular inflammation.
Findings suggest potential therapeutic relevance of targeting TSP4 pathways.

Implication

Research reveals modulation of thrombospondin-4 limits vascular inflammation in abdominal aortic aneurysm, suggesting therapeutic potential.

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Cite This Study

Blanco‐Casoliva et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba1818185d8a3980291d https://doi.org/10.1111/bph.70402

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Thrombospondin-1 (TSP1) Contributes to the Development of Vascular Inflammation by Regulating Monocytic Cell Motility in Mouse Models of Abdominal Aortic AneurysmOriginal Research · 2015 · 132 citations
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3Cell-dependent contributions of thrombospondin-1 to the rupture of abdominal aortic aneurysm in mice2025
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5Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levelscohort · 2011 · 23 citations