This case observes the relationship of warfarin anticoagulant effect and prothrombin time in a pediatric patient, suggesting careful monitoring during carbamazepine discontinuation.
This case demonstrates an inverse relationship between serum carbamazepine concentration and the prothrombin time–international normalized ratio (PT‐INR) adjusted for the warfarin dose. The concomitant use of sodium valproate further contributes to an unstable PT‐INR, emphasizing the importance of careful and continuous monitoring of anticoagulant effects.
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Shirayama et al. (2026) studied this question.
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