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March 14, 2026PLoS ONE0 citationsOpen Access

NFIC suppressed the development of Glioma via modulating the balance of SHP2/PI3K and NF-κB/PTEN Signaling

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HBHongen BaoKLK. LiuNGNaikang Gao

Key Points

  • This research examines how NFIC affects glioma development through specific signalling pathways.
  • Analyzed the role of NFIC in modulating SHP2/PI3K and NF-κB/PTEN signaling pathways.
  • Studied the relationship between NFIC expression and glioma proliferation.
  • Findings indicate NFIC inhibits glioma proliferation.
  • Activation of OGN and PTEN was linked to NFIC-mediated inhibition of the PI3K/AKT signalling pathway.

Abstract

The overexpression of NFIC has the capacity to inhibit the PI3K/AKT signalling pathway, a process facilitated by the promotion of the expression of OGN and PTEN. This, consequently, results in the inhibition of glioma proliferation and development.

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Cite This Study

Bao et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba3618185d8a3980300fhttps://doi.org/10.1371/journal.pone.0341816
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