The framework reveals how cohesin factors regulate loop extrusion and influence chromatin structure.
In this issue of Cell Genomics, Tortora and Fudenberg develop a first-principles framework in which loop extrusion is quantitatively regulated by multiple cohesin-associated factors, giving rise to "bursty extrusion." This model predicts regulator-dependent changes in motor kinetics, chromatin contact patterns, and chromosome-scale morphology across spatial scales, providing a mechanistically grounded basis for quantitative modeling of 3D genome architecture.
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Huang et al. (2026) studied this question.
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