Systematic review reveals mirtazapine effectively treats anxiety and PTSD, suggesting benefits for those with sleep disturbances.
Mirtazapine was more effective than SSRIs for anxiety in MDD and may be preferred when anxiety is relevant. In GAD, mirtazapine may serve as an alternative to first-line agents, and further regulatory explorations are warranted. In PTSD, mirtazapine has potential as an augmentation strategy. Mirtazapine was generally well tolerated and may be advantageous for patients requiring rapid effect or relief from sleep disturbances.
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Caiazza et al. (2026) studied this question.
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