What does this research mean for the field?

Mirtazapine is an effective and well-tolerated treatment for major depressive disorder patients who fail SSRI therapy, and an immediate switch from an SSRI to mirtazapine is as safe and effective as utilizing a 4-day washout period. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 15, 2001The Journal of Clinical Psychiatry

Efficacy and Safety of Mirtazapine in Major Depressive Disorder Patients After SSRI Treatment Failure

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Why the study?

Does mirtazapine improve depression symptoms in outpatients with major depressive disorder who failed SSRI therapy?

Population

103 outpatients with DSM-IV major depressive disorder who had failed previous therapy with an SSRI

Comparison

Mirtazapine treatment for 8 weeks vs Immediate switch from SSRI to mirtazapine…

Design

Cohort, open-label

Follow-up

8 weeks

Authors

MFMaurizio FavaHarvard University DDDavid L. DünnerUniversity of Washington JGJohn H. GreistUniversity of Iowa

Discussion

Member takes

Implication

Mirtazapine may support options after SSRI failure; hypothesis-generating for immediate switching pending randomized trials.

Structured PICO

Does mirtazapine improve depression symptoms in outpatients with major depressive disorder who failed SSRI therapy?

Population

103 outpatients with DSM-IV major depressive disorder who had failed previous therapy with an SSRI (fluoxetine, paroxetine, or sertraline)

Intervention

Mirtazapine treatment for 8 weeks

Comparator

Immediate switch from SSRI to mirtazapine compared with a 4-day washout period followed by mirtazapine

Outcome

17-item Hamilton Rating Scale for Depression (HAM-D-17)patient reported

An immediate switch to mirtazapine is a valid, effective, and well-tolerated therapeutic option for patients who do not respond to or tolerate SSRIs.

Cite This Study

Fava et al. (2001) studied this question.

synapsesocial.com/papers/6a1d37b928423f2ce504e30e https://doi.org/10.4088/jcp.v62n0603

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Efficacy and Safety of Mirtazapine in Major Depressive Disorder Patients After SSRI Treatment Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Efficacy and Safety of Mirtazapine in Major Depressive Disorder Patients After SSRI Treatment Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider